Genetics of Transcription
Francisco Navarro is Ph.D. in Biology (1996) from the University of Seville. During his doctoral thesis he conducted biochemical and molecular studies of nitrogen assimilation pathways in cyanobacteria. He made two postdoctoral stays: at the Jacques Monod Institute (Paris, France), focused on transcriptional regulation and cell division in bacteria, and later at the Department of Biochemistry and Molecular Biology (CEA-Saclay, France) where he began his research career in the field of transcription machinery (RNA polymerases) and genetics of transcription in the yeast Saccharomyces cerevisiae.
In 2003 got a position of «profesor titular» at the University of Jaén and since 2018 he is «catedrático» of Genetics at the same university.
Between 2015-2019 he was “Director de los Servicios Centrales de Apoyo a la Investigación” at the University of Jaén.
Since 2003 leads a research group mainly focused on the study of gene expression at the transcriptional level. His research addresses the role of RNA polymerases (RNA pols) and some of their associated factors, as well as the impact that the biogenesis of RNA pols and the prefoldin-like Bud27 have on the activity of RNA pols and on the coordination with the TOR pathway, using the experimental model Saccharomyces cerevisiae.
- Jorge Pérez Fernández
- Ana Isabel Garrido Godino
- Manuel Martín Expósito
- Francisco Gutiérrez Santiago
In our group we investigate the role that the transcriptional machinery (RNA polymerases, RNA pols) and some of their associated factors have on the synthesis, stability and degradation of mRNAs, and how they are coordinated to carry out these processes, as well as the connection and coordination between the activities of the three RNA pols. In addition, we studied how the biogenesis of RNA pols influences transcription processes.
Furthermore, part of our work addresses the role of the prefoldin-like Bud27 in the coordination of the activity of the three RNA pols and the TOR pathway.
We use the yeast Saccharomyces cerevisiae as experimental model, although we explore some of our results in human cells.
The new lines to be developed will address the molecular mechanisms that couple RNA synthesis with the formation and assembly of RNPs in eukaryotic cells, using Saccharomyces cerevisiae ribosome biosynthesis as a model.