mRNA Formation and Function

Carles Mª Suñé Negre   > ORCID   0000-0002-7991-0458

Web  www.ipb.csic.es/departamentos/csune_ingles.html?depto=MolecularBiologyDepartment
Tel.  +34 958 181 645
Mail  csune@ipb.csic.es


1985        B.S. in Pharmacy. Universidad de Barcelona. Spain.

1989        Ph.D. in Pharmacy (Biochemistry and Molecular Biology). Universidad de Barcelona. Spain

Professional Experience

1986-1990: Predoctoral Fellow, Centro de Biología Molecular (CBMSO), CSIC-UAM, Madrid, Spain. Advisor: Dr. Luis Enjuanes

1990-1991: Postdoctoral Fellow, Centro de Biología Molecular (CBMSO), CSIC-UAM, Madrid, Spain. Advisor: Dr. Luis Enjuanes

1992-1999: Research Associate, Department of Pharmacology and Cancer Biology, Duke University Medical Center (DUMC), Durham, North Carolina. USA. Advisor: Dr. Mariano A. Garcia-Blanco

2000-2001: Scientific Investigator.  Department of Medical Research.  Institute of Medical Microbiology.  University of Basel.  Switzerland. Advisor: Dr. Thomas Klimkait

2001-2006: Tenured Scientist at the Department of Molecular and Cellular Biology. Centro Nacional de Biotecnología (CNB), CSIC-UAM, Madrid. Spain

2006–Present: Tenured Scientist at the Department of Molecular Biology. Instituto de Parasitología y Biomedicina “López Neyra” (IPBLN-CSIC), Granada. Spain

  • Silvia Prieto Sánchez  lnk
  • Cristina Moreno Castro lnk
  • Younes  El Yousfi El Mourabit lnk
  • Sofía Boyero Corral
  • Marc Suñé Pou lnk



The tightly regulated process of precursor messenger RNA (pre-mRNA) alternative splicing is a key mechanism to increase the number and complexity of proteins encoded by the genome. Changes in the regulation of this process can cause multiple pathologies as a result of aberrant pre-mRNA processing underscoring the fundamental importance of this regulatory process. Evidence gathered in recent years has established that transcription and splicing are physically and functionally coupled and that this coupling may be an essential aspect of the regulation of gene expression programs. Despite considerable efforts, numerous questions remain regarding the functional significance and global impact of this coupling on cellular and organism homeostasis as well as its underlying molecular mechanisms.  In addition to study the molecular events that govern the interactions between the transcription and splicing machineries, we want to go further and provide new insights regarding the molecular mechanisms at work in pathological situations, such as neurodegenerative disorders and cancer.

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