mRNA Formation and Function
1985 B.S. in Pharmacy. Universidad de Barcelona. Spain.
1989 Ph.D. in Pharmacy (Biochemistry and Molecular Biology). Universidad de Barcelona. Spain
1986-1990: Predoctoral Fellow, Centro de Biología Molecular (CBMSO), CSIC-UAM, Madrid, Spain. Advisor: Dr. Luis Enjuanes
1990-1991: Postdoctoral Fellow, Centro de Biología Molecular (CBMSO), CSIC-UAM, Madrid, Spain. Advisor: Dr. Luis Enjuanes
1992-1999: Research Associate, Department of Pharmacology and Cancer Biology, Duke University Medical Center (DUMC), Durham, North Carolina. USA. Advisor: Dr. Mariano A. Garcia-Blanco
2000-2001: Scientific Investigator. Department of Medical Research. Institute of Medical Microbiology. University of Basel. Switzerland. Advisor: Dr. Thomas Klimkait
2001-2006: Tenured Scientist at the Department of Molecular and Cellular Biology. Centro Nacional de Biotecnología (CNB), CSIC-UAM, Madrid. Spain
2006–Present: Tenured Scientist at the Department of Molecular Biology. Instituto de Parasitología y Biomedicina “López Neyra” (IPBLN-CSIC), Granada. Spain
The tightly regulated process of precursor messenger RNA (pre-mRNA) alternative splicing is a key mechanism to increase the number and complexity of proteins encoded by the genome. Changes in the regulation of this process can cause multiple pathologies as a result of aberrant pre-mRNA processing underscoring the fundamental importance of this regulatory process. Evidence gathered in recent years has established that transcription and splicing are physically and functionally coupled and that this coupling may be an essential aspect of the regulation of gene expression programs. Despite considerable efforts, numerous questions remain regarding the functional significance and global impact of this coupling on cellular and organism homeostasis as well as its underlying molecular mechanisms. In addition to study the molecular events that govern the interactions between the transcription and splicing machineries, we want to go further and provide new insights regarding the molecular mechanisms at work in pathological situations, such as neurodegenerative disorders and cancer.